Complex wounds that are difficult to heal represent a major focus for tissue engineering and
regenerative medicine strategies. Skin substitutes, composed of living cells grown in a laboratory, are
used to heal these types of wounds. Additionally, growth factors are being explored for improving
wound healing. One of the most significant breakthroughs in regenerative therapy for wound healing
has been the use of negative pressure devices. Discovered by a plastic surgeon, these devices use
negative pressure and micro-mechanical forces to stimulate wound healing.